BRD-A19633847_PERHEXILINE MALEATE_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DST dystonin
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PER1 period circadian clock 1
PTN pleiotrophin
RB1CC1 RB1-inducible coiled-coil 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ATP10B ATPase, class V, type 10B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BST2 bone marrow stromal cell antigen 2
CANT1 calcium activated nucleotidase 1
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD164 CD164 molecule, sialomucin
CD320 CD320 molecule
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDH17 cadherin 17, LI cadherin (liver-intestine)
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCTD dCMP deaminase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DYNLL1 dynein, light chain, LC8-type 1
EDF1 endothelial differentiation-related factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FUS FUS RNA binding protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLS glutaminase
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
KAZN kazrin, periplakin interacting protein
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCOLN1 mucolipin 1
MGST2 microsomal glutathione S-transferase 2
MLEC malectin
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPS16 mitochondrial ribosomal protein S16
MRPS2 mitochondrial ribosomal protein S2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NDP Norrie disease (pseudoglioma)
NPY neuropeptide Y
PDIA3 protein disulfide isomerase family A, member 3
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PON2 paraoxonase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD23B RAD23 homolog B (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S