BRD-A19633847_PERHEXILINE MALEATE_SNUC5_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_SNUC5_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ANKRD10 ankyrin repeat domain 10
APOC1 apolipoprotein C-I
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC34 cell division cycle 34
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRY1 cryptochrome circadian clock 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRH1 histamine receptor H1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA1324 KIAA1324
KLF6 Kruppel-like factor 6
LAMP5 lysosomal-associated membrane protein family, member 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MT1F metallothionein 1F
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB31 RAB31, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMC1A structural maintenance of chromosomes 1A
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TANK TRAF family member-associated NFKB activator
TBPL1 TBP-like 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM110 transmembrane protein 110
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB2 transducer of ERBB2, 2
TRIM36 tripartite motif containing 36
TSPYL2 TSPY-like 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANPEP alanyl (membrane) aminopeptidase
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CBX6 chromobox homolog 6
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDK6 cyclin-dependent kinase 6
CHRDL1 chordin-like 1
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FSCN1 fascin actin-bundling protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUD1 glutamate dehydrogenase 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
METRN meteorin, glial cell differentiation regulator
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRC1 protein regulator of cytokinesis 1
PSCA prostate stem cell antigen
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF9 serine/arginine-rich splicing factor 9
SUMO2 small ubiquitin-like modifier 2
SYPL1 synaptophysin-like 1
TBC1D16 TBC1 domain family, member 16
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TMED2 transmembrane emp24 domain trafficking protein 2
TMPO thymopoietin
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
VCAN versican
WSB2 WD repeat and SOCS box containing 2
XPO7 exportin 7
ZDHHC3 zinc finger, DHHC-type containing 3