BRD-A19633847_PERHEXILINE MALEATE_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CES1 carboxylesterase 1
CLGN calmegin
CNPY3 canopy FGF signaling regulator 3
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYTH1 cytohesin 1
DAAM1 dishevelled associated activator of morphogenesis 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DYNLT1 dynein, light chain, Tctex-type 1
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
EVI2A ecotropic viral integration site 2A
EZR ezrin
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
GTPBP2 GTP binding protein 2
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOPX HOP homeobox
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
JUP junction plakoglobin
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PRKCD protein kinase C, delta
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SLC38A1 solute carrier family 38, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
B3GNT1
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
C1S complement component 1, s subcomponent
CA1 carbonic anhydrase I
CANT1 calcium activated nucleotidase 1
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MRPL16 mitochondrial ribosomal protein L16
MRPS2 mitochondrial ribosomal protein S2
MUC2 mucin 2, oligomeric mucus/gel-forming
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRN1 neuritin 1
PDHX pyruvate dehydrogenase complex, component X
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTDSS1 phosphatidylserine synthase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RPL39L ribosomal protein L39-like
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT3 sirtuin 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMYD2 SET and MYND domain containing 2
SORD sorbitol dehydrogenase
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TOX thymocyte selection-associated high mobility group box