BRD-A19633847_PERHEXILINE MALEATE_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C2CD2 C2 calcium-dependent domain containing 2
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC92 coiled-coil domain containing 92
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHCR7 7-dehydrocholesterol reductase
DRAM1 DNA-damage regulated autophagy modulator 1
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HBB hemoglobin, beta
HDAC6 histone deacetylase 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LITAF lipopolysaccharide-induced TNF factor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDZD2 PDZ domain containing 2
PHGDH phosphoglycerate dehydrogenase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS1 regulator of G-protein signaling 1
RGS3 regulator of G-protein signaling 3
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RYBP RING1 and YY1 binding protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEPT10 septin 10
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZFAND1 zinc finger, AN1-type domain 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
BAG2 BCL2-associated athanogene 2
C3 complement component 3
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD3EAP CD3e molecule, epsilon associated protein
CHD7 chromodomain helicase DNA binding protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHPT1 choline phosphotransferase 1
COCH cochlin
COL15A1 collagen, type XV, alpha 1
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOXC1 forkhead box C1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTT1 glutathione S-transferase theta 1
HHEX hematopoietically expressed homeobox
HN1 hematological and neurological expressed 1
HP haptoglobin
HSPH1 heat shock 105kDa/110kDa protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KCTD12 potassium channel tetramerization domain containing 12
KRT10 keratin 10, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
LPL lipoprotein lipase
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA5 melanoma antigen family A5
MAGEA6 melanoma antigen family A6
MATN2 matrilin 2
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MID1 midline 1
MSRA methionine sulfoxide reductase A
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDZRN3 PDZ domain containing ring finger 3
PER2 period circadian clock 2
PMP22 peripheral myelin protein 22
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
PUS7 pseudouridylate synthase 7 (putative)
RAB2A RAB2A, member RAS oncogene family
RNASE3 ribonuclease, RNase A family, 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SEPT9 septin 9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SRM spermidine synthase
TESC tescalcin
TGFBI transforming growth factor, beta-induced, 68kDa
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WDR12 WD repeat domain 12
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing