BRD-A19633847_PERHEXILINE MALEATE_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
APOD apolipoprotein D
C3 complement component 3
CD163 CD163 molecule
CLEC7A C-type lectin domain family 7, member A
CPE carboxypeptidase E
DDIT4 DNA-damage-inducible transcript 4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETV1 ets variant 1
FOXO1 forkhead box O1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100A9 S100 calcium binding protein A9
SASH1 SAM and SH3 domain containing 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TTC39A tetratricopeptide repeat domain 39A
TWIST1 twist family bHLH transcription factor 1
TXNDC9 thioredoxin domain containing 9

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
BCLAF1 BCL2-associated transcription factor 1
BIRC2 baculoviral IAP repeat containing 2
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNB2 ephrin-B2
EPN2 epsin 2
FAM57A family with sequence similarity 57, member A
LYPLA1 lysophospholipase I
MRPS2 mitochondrial ribosomal protein S2
NOP16 NOP16 nucleolar protein
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF7 serine/arginine-rich splicing factor 7
TDG thymine-DNA glycosylase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)