BRD-A19633847_PERHEXILINE MALEATE_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EREG epiregulin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGA4 golgin A4
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SKAP2 src kinase associated phosphoprotein 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TRAK2 trafficking protein, kinesin binding 2
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TTC28 tetratricopeptide repeat domain 28
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF165 zinc finger protein 165
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
BAD BCL2-associated agonist of cell death
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
DPYSL3 dihydropyrimidinase-like 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FERMT1 fermitin family member 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJA1 gap junction protein, alpha 1, 43kDa
GPC1 glypican 1
GREM1 gremlin 1, DAN family BMP antagonist
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INA internexin neuronal intermediate filament protein, alpha
KRT19 keratin 19, type I
LMNB1 lamin B1
MTCL1 microtubule crosslinking factor 1
MX2 MX dynamin-like GTPase 2
NDRG3 NDRG family member 3
NENF neudesin neurotrophic factor
NQO1 NAD(P)H dehydrogenase, quinone 1
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLEKHJ1 pleckstrin homology domain containing, family J member 1
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TRAPPC3 trafficking protein particle complex 3
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18