BRD-A19633847_PERHEXILINE MALEATE_JHUEM2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_JHUEM2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ASPN asporin
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
C5AR1 complement component 5a receptor 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDH13 cadherin 13
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CTSS cathepsin S
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GRB7 growth factor receptor-bound protein 7
GYPC glycophorin C (Gerbich blood group)
HEG1 heart development protein with EGF-like domains 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LRMP lymphoid-restricted membrane protein
LY96 lymphocyte antigen 96
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METRN meteorin, glial cell differentiation regulator
MMP3 matrix metallopeptidase 3
MPO myeloperoxidase
MXI1 MAX interactor 1, dimerization protein
NEB nebulin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP4 secreted frizzled-related protein 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SSPN sarcospan
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TLR4 toll-like receptor 4
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ANXA7 annexin A7
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C14ORF2 chromosome 14 open reading frame 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
COCH cochlin
COL4A1 collagen, type IV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCXR dicarbonyl/L-xylulose reductase
DYNLRB1 dynein, light chain, roadblock-type 1
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ITGB1BP1 integrin beta 1 binding protein 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYCBP MYC binding protein
MYL9 myosin, light chain 9, regulatory
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
PCDH9 protocadherin 9
PRDX1 peroxiredoxin 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPN2 ribophorin II
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SAMM50 SAMM50 sorting and assembly machinery component
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SORD sorbitol dehydrogenase
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN3 tetraspanin 3
UBE3B ubiquitin protein ligase E3B
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)