BRD-A19633847_PERHEXILINE MALEATE_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGB chromogranin B
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELOVL5 ELOVL fatty acid elongase 5
FADS1 fatty acid desaturase 1
FBN2 fibrillin 2
FBXO11 F-box protein 11
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSM1 insulinoma-associated 1
KLHL24 kelch-like family member 24
LGALS1 lectin, galactoside-binding, soluble, 1
LRP10 low density lipoprotein receptor-related protein 10
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MGLL monoglyceride lipase
MSX1 msh homeobox 1
MTSS1 metastasis suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MVP major vault protein
MYO1D myosin ID
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
OPTN optineurin
PAX5 paired box 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PFKM phosphofructokinase, muscle
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PNMA2 paraneoplastic Ma antigen 2
PRSS8 protease, serine, 8
PTPRD protein tyrosine phosphatase, receptor type, D
PXDN peroxidasin
RHOQ ras homolog family member Q
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SI sucrase-isomaltase (alpha-glucosidase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD7 SMAD family member 7
SOD2 superoxide dismutase 2, mitochondrial
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRED2 sprouty-related, EVH1 domain containing 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF5 TNF receptor-associated factor 5
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
ZBTB18 zinc finger and BTB domain containing 18
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ANXA1 annexin A1
ATF5 activating transcription factor 5
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CHMP4A charged multivesicular body protein 4A
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CTSH cathepsin H
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EMP1 epithelial membrane protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HOPX HOP homeobox
IL1RN interleukin 1 receptor antagonist
ISOC1 isochorismatase domain containing 1
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
LYZ lysozyme
MYD88 myeloid differentiation primary response 88
MYO5C myosin VC
NME4 NME/NM23 nucleoside diphosphate kinase 4
OBSL1 obscurin-like 1
PIR pirin (iron-binding nuclear protein)
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TM4SF1 transmembrane 4 L six family member 1