BRD-A19633847_PERHEXILINE MALEATE_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIN1 bridging integrator 1
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLIC4 chloride intracellular channel 4
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
LDLR low density lipoprotein receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOF ras homolog family member F (in filopodia)
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
CD1E CD1e molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CLEC5A C-type lectin domain family 5, member A
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COLEC12 collectin sub-family member 12
EDNRA endothelin receptor type A
FGFR3 fibroblast growth factor receptor 3
LPAR6 lysophosphatidic acid receptor 6
ORC1 origin recognition complex, subunit 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCGB1D2 secretoglobin, family 1D, member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPON1 spondin 1, extracellular matrix protein
XIST X inactive specific transcript (non-protein coding)