BRD-A19633847_PERHEXILINE MALEATE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CCNG2 cyclin G2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLK11 kallikrein-related peptidase 11
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPTN optineurin
PEG10 paternally expressed 10
PENK proenkephalin
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
CCND1 cyclin D1
CDC25A cell division cycle 25A
CNPY3 canopy FGF signaling regulator 3
CYB5A cytochrome b5 type A (microsomal)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MTCL1 microtubule crosslinking factor 1
MYH10 myosin, heavy chain 10, non-muscle
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB38 RAB38, member RAS oncogene family
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)