BRD-A19633847_PERHEXILINE MALEATE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
CTSB cathepsin B
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DHDDS dehydrodolichyl diphosphate synthase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ICAM1 intercellular adhesion molecule 1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KLHL24 kelch-like family member 24
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
PSAP prosaposin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
TKT transketolase
TMEM41B transmembrane protein 41B
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
H2AFX H2A histone family, member X
HEG1 heart development protein with EGF-like domains 1
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP107 nucleoporin 107kDa
NUP85 nucleoporin 85kDa
PCNA proliferating cell nuclear antigen
PRC1 protein regulator of cytokinesis 1
RANBP1 RAN binding protein 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein