BRD-A19633847_PERHEXILINE MALEATE_HCC15_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C3ORF14 chromosome 3 open reading frame 14
CCR2 chemokine (C-C motif) receptor 2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CES2 carboxylesterase 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
ENOPH1 enolase-phosphatase 1
FAM69A family with sequence similarity 69, member A
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD1 frizzled class receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GSE1 Gse1 coiled-coil protein
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTMR11 myotubularin related protein 11
NEB nebulin
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRL platelet-derived growth factor receptor-like
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TENM1 teneurin transmembrane protein 1
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
CALD1 caldesmon 1
CCND1 cyclin D1
CD320 CD320 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN1 claudin 1
CLU clusterin
COL4A2 collagen, type IV, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTSG cathepsin G
CYTL1 cytokine-like 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
GATA2 GATA binding protein 2
GLIPR1 GLI pathogenesis-related 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NGRN neugrin, neurite outgrowth associated
NPY neuropeptide Y
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPF4 pre-mRNA processing factor 4
PTGES prostaglandin E synthase
RPA3 replication protein A3, 14kDa
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMX4 thioredoxin-related transmembrane protein 4
TSPAN13 tetraspanin 13