BRD-A19633847_PERHEXILINE MALEATE_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZU1 azurocidin 1
BACE2 beta-site APP-cleaving enzyme 2
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CCR1 chemokine (C-C motif) receptor 1
CD4 CD4 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CFP complement factor properdin
CLC Charcot-Leyden crystal galectin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EHD1 EH-domain containing 1
ELF1 E74-like factor 1 (ets domain transcription factor)
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FYB FYN binding protein
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LTF lactotransferrin
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PAX8 paired box 8
PER1 period circadian clock 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TPD52L1 tumor protein D52-like 1
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UGDH UDP-glucose 6-dehydrogenase
USP18 ubiquitin specific peptidase 18
VNN1 vanin 1
XAF1 XIAP associated factor 1
XBP1 X-box binding protein 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
CALR calreticulin
CAST calpastatin
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP2 cysteine-rich protein 2
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
ECI2 enoyl-CoA delta isomerase 2
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSTL1 follistatin-like 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
MCAM melanoma cell adhesion molecule
MLANA melan-A
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NES nestin
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDHX pyruvate dehydrogenase complex, component X
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD3 protein kinase D3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM14A transmembrane protein 14A
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZIC1 Zic family member 1