BRD-A19633847_PERHEXILINE MALEATE_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALB albumin
ANK2 ankyrin 2, neuronal
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATXN1 ataxin 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNI cyclin I
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FBXL12 F-box and leucine-rich repeat protein 12
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLS glutaminase
GRB10 growth factor receptor-bound protein 10
GSTA1 glutathione S-transferase alpha 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHA1 immunoglobulin heavy constant alpha 1
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK5 proprotein convertase subtilisin/kexin type 5
PHGDH phosphoglycerate dehydrogenase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB29 RAB29, member RAS oncogene family
RNF167 ring finger protein 167
RPS5 ribosomal protein S5
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERINC3 serine incorporator 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFXN3 sideroflexin 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOBP sine oculis binding protein homolog (Drosophila)
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TRIP6 thyroid hormone receptor interactor 6
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRA3 adhesion G protein-coupled receptor A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
B3GNT1
BAG2 BCL2-associated athanogene 2
BCLAF1 BCL2-associated transcription factor 1
CCL2 chemokine (C-C motif) ligand 2
CDC25A cell division cycle 25A
CXCL9 chemokine (C-X-C motif) ligand 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
GTPBP4 GTP binding protein 4
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
LCN2 lipocalin 2
LMNB1 lamin B1
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PTPRC protein tyrosine phosphatase, receptor type, C
RBM12 RNA binding motif protein 12
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFPQ splicing factor proline/glutamine-rich
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SRSF3 serine/arginine-rich splicing factor 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUMO3 small ubiquitin-like modifier 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCTA T-cell leukemia translocation altered
THBS1 thrombospondin 1
TMEM168 transmembrane protein 168
TP73-AS1 TP73 antisense RNA 1
TSPAN13 tetraspanin 13
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UMPS uridine monophosphate synthetase
UNG uracil-DNA glycosylase
ZBTB20 zinc finger and BTB domain containing 20