BRD-A19500257_geldanamycin_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A19500257_geldanamycin_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP9A ATPase, class II, type 9A
CA12 carbonic anhydrase XII
CAPN6 calpain 6
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CRABP1 cellular retinoic acid binding protein 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGG fibrinogen gamma chain
FMO3 flavin containing monooxygenase 3
G6PD glucose-6-phosphate dehydrogenase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GUSBP11 glucuronidase, beta pseudogene 11
GZMK granzyme K (granzyme 3; tryptase II)
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
NPR3 natriuretic peptide receptor 3
NYNRIN NYN domain and retroviral integrase containing
PIR pirin (iron-binding nuclear protein)
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAI14 retinoic acid induced 14
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOD1 superoxide dismutase 1, soluble
STAT4 signal transducer and activator of transcription 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNPO1 transportin 1
TP53I3 tumor protein p53 inducible protein 3
TPSAB1 tryptase alpha/beta 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4A ADP-ribosylation factor-like 4A
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DCN decorin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F3 coagulation factor III (thromboplastin, tissue factor)
FILIP1L filamin A interacting protein 1-like
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GFAP glial fibrillary acidic protein
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GRAMD3 GRAM domain containing 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INHBA inhibin, beta A
KLF4 Kruppel-like factor 4 (gut)
LONP2 lon peptidase 2, peroxisomal
LRRC15 leucine rich repeat containing 15
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QPCT glutaminyl-peptide cyclotransferase
RAB32 RAB32, member RAS oncogene family
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SCG5 secretogranin V
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TXNDC9 thioredoxin domain containing 9
UBL3 ubiquitin-like 3
VCAN versican