BRD-A19500257_geldanamycin_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A19500257_geldanamycin_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLGN calmegin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CRABP2 cellular retinoic acid binding protein 2
CRISP3 cysteine-rich secretory protein 3
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT1 dynein, light chain, Tctex-type 1
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HDLBP high density lipoprotein binding protein
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ITM2C integral membrane protein 2C
LOC100505650 uncharacterized LOC100505650
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MGAM maltase-glucoamylase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOSPD1 motile sperm domain containing 1
MUT methylmalonyl CoA mutase
ORM1 orosomucoid 1
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PFN2 profilin 2
PLXNB2 plexin B2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PXN paxillin
RAB13 RAB13, member RAS oncogene family
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHB Src homology 2 domain containing adaptor protein B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TDO2 tryptophan 2,3-dioxygenase
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
C6ORF62 chromosome 6 open reading frame 62
C8ORF33 chromosome 8 open reading frame 33
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCNB1 cyclin B1
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENOPH1 enolase-phosphatase 1
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FBLN5 fibulin 5
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GOLGA8A golgin A8 family, member A
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOMER1 homer scaffolding protein 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
LPL lipoprotein lipase
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MEOX2 mesenchyme homeobox 2
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NRN1 neuritin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PPA1 pyrophosphatase (inorganic) 1
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RNASET2 ribonuclease T2
RPP40 ribonuclease P/MRP 40kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SERBP1 SERPINE1 mRNA binding protein 1
SFPQ splicing factor proline/glutamine-rich
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC43A3 solute carrier family 43, member 3
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM5 transmembrane protein 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNIP thioredoxin interacting protein
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE3C ubiquitin protein ligase E3C