BRD-A19500257_geldanamycin_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-A19500257_geldanamycin_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AQP9 aquaporin 9
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC5A C-type lectin domain family 5, member A
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
DCN decorin
DSP desmoplakin
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HOPX HOP homeobox
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HYOU1 hypoxia up-regulated 1
IL1R1 interleukin 1 receptor, type I
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA2 surfactant protein A2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STON1 stonin 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L2 tumor protein D52-like 2
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DSG3 desmoglein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GLIPR1 GLI pathogenesis-related 1
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
KAZN kazrin, periplakin interacting protein
LAMP1 lysosomal-associated membrane protein 1
LIMA1 LIM domain and actin binding 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PWP1 PWP1 homolog (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A6 S100 calcium binding protein A6
SFRP1 secreted frizzled-related protein 1
SRSF7 serine/arginine-rich splicing factor 7
TNC tenascin C
TRAF4 TNF receptor-associated factor 4