BRD-A19500257_geldanamycin_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A19500257_geldanamycin_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
CALR calreticulin
CANX calnexin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
JUP junction plakoglobin
LOC100272216 uncharacterized LOC100272216
MME membrane metallo-endopeptidase
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUCB2 nucleobindin 2
OSBPL1A oxysterol binding protein-like 1A
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA4 protein disulfide isomerase family A, member 4
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRAME preferentially expressed antigen in melanoma
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC35B1 solute carrier family 35, member B1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ATF1 activating transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C3 complement component 3
CCDC47 coiled-coil domain containing 47
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK6 cyclin-dependent kinase 6
CETN3 centrin, EF-hand protein, 3
CHD7 chromodomain helicase DNA binding protein 7
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CORO1C coronin, actin binding protein, 1C
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DLD dihydrolipoamide dehydrogenase
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GAS2L1 growth arrest-specific 2 like 1
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HSPA14 heat shock 70kDa protein 14
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
JAG1 jagged 1
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
LPXN leupaxin
LRRN3 leucine rich repeat neuronal 3
LXN latexin
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MXRA5 matrix-remodelling associated 5
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLAT plasminogen activator, tissue
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUS7 pseudouridylate synthase 7 (putative)
PWP1 PWP1 homolog (S. cerevisiae)
RTN1 reticulon 1
S100A13 S100 calcium binding protein A13
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
STK26 serine/threonine protein kinase 26
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNDC9 thioredoxin domain containing 9
UBE3B ubiquitin protein ligase E3B
UBE3C ubiquitin protein ligase E3C
USP33 ubiquitin specific peptidase 33
WEE1 WEE1 G2 checkpoint kinase