BRD-A19500257_geldanamycin_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A19500257_geldanamycin_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
CBX1 chromobox homolog 1
CCNI cyclin I
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CYLD cylindromatosis (turban tumor syndrome)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELL2 elongation factor, RNA polymerase II, 2
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HYOU1 hypoxia up-regulated 1
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF5B kinesin family member 5B
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
NKX3-1 NK3 homeobox 1
NOD2 nucleotide-binding oligomerization domain containing 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA3 protein disulfide isomerase family A, member 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDF2L1 stromal cell-derived factor 2-like 1
SEC61B Sec61 beta subunit
SELL selectin L
SFTPC surfactant protein C
SLAMF7 SLAM family member 7
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM45A transmembrane protein 45A
TNPO1 transportin 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
BCAP31 B-cell receptor-associated protein 31
C3 complement component 3
CA12 carbonic anhydrase XII
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
DEPTOR DEP domain containing MTOR-interacting protein
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
GLI2 GLI family zinc finger 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSTK1 glutathione S-transferase kappa 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTF3A general transcription factor IIIA
HHEX hematopoietically expressed homeobox
HILPDA hypoxia inducible lipid droplet-associated
HTRA1 HtrA serine peptidase 1
ICT1 immature colon carcinoma transcript 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT7 keratin 7, type II
LHFP lipoma HMGIC fusion partner
LSR lipolysis stimulated lipoprotein receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MRPL15 mitochondrial ribosomal protein L15
MRPS7 mitochondrial ribosomal protein S7
MYBPC1 myosin binding protein C, slow type
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NUP85 nucleoporin 85kDa
PEBP1 phosphatidylethanolamine binding protein 1
PEG3 paternally expressed 3
PLIN2 perilipin 2
PLN phospholamban
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF6 serine/arginine-rich splicing factor 6
STC1 stanniocalcin 1
SYNGR2 synaptogyrin 2
TBC1D16 TBC1 domain family, member 16
THY1 Thy-1 cell surface antigen
TIMP1 TIMP metallopeptidase inhibitor 1
TPM2 tropomyosin 2 (beta)
TTN titin