BRD-A19500257_geldanamycin_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-A19500257_geldanamycin_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
BPTF bromodomain PHD finger transcription factor
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CKAP4 cytoskeleton-associated protein 4
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFL6 EGF-like-domain, multiple 6
EMX2 empty spiracles homeobox 2
EPAS1 endothelial PAS domain protein 1
EPYC epiphycan
FAM69A family with sequence similarity 69, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
HOXB6 homeobox B6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2C integral membrane protein 2C
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LOXL2 lysyl oxidase-like 2
MAP7 microtubule-associated protein 7
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4DIP phosphodiesterase 4D interacting protein
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHB Src homology 2 domain containing adaptor protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TPBG trophoblast glycoprotein
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
C3 complement component 3
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CHI3L2 chitinase 3-like 2
CHPT1 choline phosphotransferase 1
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEMIN4 gem (nuclear organelle) associated protein 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HHEX hematopoietically expressed homeobox
HN1 hematological and neurological expressed 1
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL13RA2 interleukin 13 receptor, alpha 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KIF5C kinesin family member 5C
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LEPR leptin receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP16 NOP16 nucleolar protein
NREP neuronal regeneration related protein
NRN1 neuritin 1
PGK1 phosphoglycerate kinase 1
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PUS7 pseudouridylate synthase 7 (putative)
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RFTN1 raftlin, lipid raft linker 1
RPL37A ribosomal protein L37a
RPP40 ribonuclease P/MRP 40kDa subunit
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SNN stannin
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
UBE3C ubiquitin protein ligase E3C
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB18 zinc finger and BTB domain containing 18