BRD-A19500257_geldanamycin_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AHNAK2 AHNAK nucleoprotein 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
CANX calnexin
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CD300A CD300a molecule
CD99 CD99 molecule
CHN1 chimerin 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIP1 CAP-GLY domain containing linker protein 1
CLU clusterin
CTBS chitobiase, di-N-acetyl-
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4B eukaryotic translation initiation factor 4B
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGB1 golgin B1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MLEC malectin
MTUS1 microtubule associated tumor suppressor 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA6 protein disulfide isomerase family A, member 6
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RHOBTB3 Rho-related BTB domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERINC1 serine incorporator 1
SERP1 stress-associated endoplasmic reticulum protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRRM2 serine/arginine repetitive matrix 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TRA2A transformer 2 alpha homolog (Drosophila)
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UGDH UDP-glucose 6-dehydrogenase
WIF1 WNT inhibitory factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB38 zinc finger and BTB domain containing 38
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHRDL1 chordin-like 1
COL14A1 collagen, type XIV, alpha 1
CRIP2 cysteine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCT dopachrome tautomerase
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
FABP4 fatty acid binding protein 4, adipocyte
FAR2 fatty acyl CoA reductase 2
FGFR3 fibroblast growth factor receptor 3
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GLDC glycine dehydrogenase (decarboxylating)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HOXB2 homeobox B2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JADE2 jade family PHD finger 2
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MMP12 matrix metallopeptidase 12
MYH11 myosin, heavy chain 11, smooth muscle
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
OLFM4 olfactomedin 4
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PUF60 poly-U binding splicing factor 60KDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RNF144A ring finger protein 144A
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC35G2 solute carrier family 35, member G2
SLIRP SRA stem-loop interacting RNA binding protein
SMAD7 SMAD family member 7
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2