BRD-A19500257_geldanamycin_SKBR3_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AGR2 anterior gradient 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD3D CD3d molecule, delta (CD3-TCR complex)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
CSTA cystatin A (stefin A)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FXR1 fragile X mental retardation, autosomal homolog 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LAPTM4B lysosomal protein transmembrane 4 beta
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MBNL2 muscleblind-like splicing regulator 2
MICB MHC class I polypeptide-related sequence B
MT1M metallothionein 1M
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PON2 paraoxonase 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SEC62 SEC62 homolog (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX10 sorting nexin 10
STAR steroidogenic acute regulatory protein
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
VAMP8 vesicle-associated membrane protein 8
WBP5 WW domain binding protein 5
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CA2 carbonic anhydrase II
CD9 CD9 molecule
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CST1 cystatin SN
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPP4 dipeptidyl-peptidase 4
EDNRB endothelin receptor type B
EGR3 early growth response 3
FAS Fas cell surface death receptor
FBL fibrillarin
FOXG1 forkhead box G1
FRZB frizzled-related protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS7 growth arrest-specific 7
GDF15 growth differentiation factor 15
GRB14 growth factor receptor-bound protein 14
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KLF10 Kruppel-like factor 10
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MNDA myeloid cell nuclear differentiation antigen
MYLK myosin light chain kinase
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTN pleiotrophin
PUF60 poly-U binding splicing factor 60KDa
RTN1 reticulon 1
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCF4 transcription factor 4
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TKT transketolase
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L2 ZFP36 ring finger protein-like 2