BRD-A19500257_geldanamycin_SKBR3_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
BAG3 BCL2-associated athanogene 3
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
KLF9 Kruppel-like factor 9
LYPD1 LY6/PLAUR domain containing 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MAOB monoamine oxidase B
MSLN mesothelin
MT1F metallothionein 1F
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TOM1L1 target of myb1 (chicken)-like 1
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
APMAP adipocyte plasma membrane associated protein
AQP3 aquaporin 3 (Gill blood group)
ARMCX2 armadillo repeat containing, X-linked 2
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CTSS cathepsin S
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBXO21 F-box protein 21
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GRB14 growth factor receptor-bound protein 14
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IL1R2 interleukin 1 receptor, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
LYZ lysozyme
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
PLN phospholamban
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SST somatostatin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3