BRD-A19500257_geldanamycin_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BID BH3 interacting domain death agonist
C1QB complement component 1, q subcomponent, B chain
CEP57 centrosomal protein 57kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DEFB4A defensin, beta 4A
DICER1 dicer 1, ribonuclease type III
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FXR1 fragile X mental retardation, autosomal homolog 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
MCUR1 mitochondrial calcium uniporter regulator 1
MYO1B myosin IB
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
PCOLCE procollagen C-endopeptidase enhancer
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SMAD3 SMAD family member 3
TDO2 tryptophan 2,3-dioxygenase
TES testin LIM domain protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRA2A transformer 2 alpha homolog (Drosophila)
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKIRIN1 akirin 1
ANK2 ankyrin 2, neuronal
ANXA6 annexin A6
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CD200 CD200 molecule
CDC25A cell division cycle 25A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLGN calmegin
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST1 cystatin SN
CTSG cathepsin G
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCT dopachrome tautomerase
DEFA4 defensin, alpha 4, corticostatin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FBN1 fibrillin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
HBD hemoglobin, delta
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HOXB6 homeobox B6
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
LAMA3 laminin, alpha 3
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MAP1B microtubule-associated protein 1B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MPO myeloperoxidase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2A phosphatidic acid phosphatase type 2A
PPIF peptidylprolyl isomerase F
PPL periplakin
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RTN1 reticulon 1
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
STMN2 stathmin 2
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
ZMIZ1 zinc finger, MIZ-type containing 1