BRD-A19500257_geldanamycin_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADGRG6 adhesion G protein-coupled receptor G6
ADGRL2 adhesion G protein-coupled receptor L2
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP13 A kinase (PRKA) anchor protein 13
AKAP9 A kinase (PRKA) anchor protein 9
ALDOB aldolase B, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ATF7IP2 activating transcription factor 7 interacting protein 2
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BRD8 bromodomain containing 8
C1ORF115 chromosome 1 open reading frame 115
C1ORF54 chromosome 1 open reading frame 54
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDC14B cell division cycle 14B
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CLDN8 claudin 8
CLEC11A C-type lectin domain family 11, member A
COBL cordon-bleu WH2 repeat protein
COL1A2 collagen, type I, alpha 2
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYZ crystallin, zeta (quinone reductase)
CXCL13 chemokine (C-X-C motif) ligand 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DST dystonin
EDN3 endothelin 3
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FBXW2 F-box and WD repeat domain containing 2
FNBP1 formin binding protein 1
FOXD1 forkhead box D1
FOXJ3 forkhead box J3
FST follistatin
FTO fat mass and obesity associated
FXR1 fragile X mental retardation, autosomal homolog 1
FZD2 frizzled class receptor 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
GPNMB glycoprotein (transmembrane) nmb
GRAMD3 GRAM domain containing 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP1 insulin-like growth factor binding protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
INSR insulin receptor
ITM2C integral membrane protein 2C
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1324 KIAA1324
KIF2C kinesin family member 2C
KNG1 kininogen 1
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
LDHB lactate dehydrogenase B
LRP12 low density lipoprotein receptor-related protein 12
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
MUT methylmalonyl CoA mutase
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP3 nuclear receptor interacting protein 3
NUCB2 nucleobindin 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OBSL1 obscurin-like 1
OLA1 Obg-like ATPase 1
OLFML3 olfactomedin-like 3
OXTR oxytocin receptor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PVALB parvalbumin
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM39 RNA binding motif protein 39
RBP1 retinol binding protein 1, cellular
RELN reelin
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
SATB1 SATB homeobox 1
SCPEP1 serine carboxypeptidase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDCBP syndecan binding protein (syntenin)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP1 secreted frizzled-related protein 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPAG16 sperm associated antigen 16
SPINK1 serine peptidase inhibitor, Kazal type 1
SSFA2 sperm specific antigen 2
STC2 stanniocalcin 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TPBG trophoblast glycoprotein
TSPAN6 tetraspanin 6
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VWA5A von Willebrand factor A domain containing 5A
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADGRG1 adhesion G protein-coupled receptor G1
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASRGL1 asparaginase like 1
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C20ORF24 chromosome 20 open reading frame 24
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CD52 CD52 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CYB561 cytochrome b561
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DCLK1 doublecortin-like kinase 1
DHFR dihydrofolate reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOK5 docking protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EML3 echinoderm microtubule associated protein like 3
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EXT1 exostosin glycosyltransferase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOXG1 forkhead box G1
GALE UDP-galactose-4-epimerase
GGCT gamma-glutamylcyclotransferase
GIMAP6 GTPase, IMAP family member 6
GLRX2 glutaredoxin 2
GOLGA8B golgin A8 family, member B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
ITGB1BP1 integrin beta 1 binding protein 1
JAG1 jagged 1
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MELK maternal embryonic leucine zipper kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MRPS16 mitochondrial ribosomal protein S16
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NXT1 nuclear transport factor 2-like export factor 1
OSBPL10 oxysterol binding protein-like 10
OSBPL3 oxysterol binding protein-like 3
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PLN phospholamban
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RBM34 RNA binding motif protein 34
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
S100A11 S100 calcium binding protein A11
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNN stannin
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TRD T cell receptor delta locus
TWF2 twinfilin actin binding protein 2
TXN thioredoxin
TYMS thymidylate synthetase
YBX3 Y box binding protein 3
ZFP36L2 ZFP36 ring finger protein-like 2