BRD-A19500257_geldanamycin_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

316 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACKR3 atypical chemokine receptor 3
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AFF1 AF4/FMR2 family, member 1
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ANKMY2 ankyrin repeat and MYND domain containing 2
ANO1 anoctamin 1, calcium activated chloride channel
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARG1 arginase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF7IP2 activating transcription factor 7 interacting protein 2
ATMIN ATM interactor
ATXN1 ataxin 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLVRA biliverdin reductase A
C1ORF54 chromosome 1 open reading frame 54
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC28A coiled-coil domain containing 28A
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYNLT3 dynein, light chain, Tctex-type 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXF2 forkhead box F2
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GDF15 growth differentiation factor 15
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTRA1 HtrA serine peptidase 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
ITM2C integral membrane protein 2C
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LCN2 lipocalin 2
MAGEA12 melanoma antigen family A12
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MME membrane metallo-endopeptidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MUT methylmalonyl CoA mutase
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPC2 Niemann-Pick disease, type C2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP3 nuclear receptor interacting protein 3
NUCB2 nucleobindin 2
OSBPL9 oxysterol binding protein-like 9
OXTR oxytocin receptor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QKI QKI, KH domain containing, RNA binding
QPRT quinolinate phosphoribosyltransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGD Ras-related GTP binding D
SATB1 SATB homeobox 1
SC5D sterol-C5-desaturase
SCG5 secretogranin V
SDCBP syndecan binding protein (syntenin)
SEC24A SEC24 family member A
SECISBP2L SECIS binding protein 2-like
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A4 solute carrier family 38, member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON2 spondin 2, extracellular matrix protein
SSFA2 sperm specific antigen 2
STK26 serine/threonine protein kinase 26
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBL1X transducin (beta)-like 1X-linked
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMED5 transmembrane emp24 protein transport domain containing 5
TOMM34 translocase of outer mitochondrial membrane 34
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
UBB ubiquitin B
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
VWA5A von Willebrand factor A domain containing 5A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZCCHC14 zinc finger, CCHC domain containing 14
ZMYM2 zinc finger, MYM-type 2
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ANXA10 annexin A10
ANXA5 annexin A5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASL argininosuccinate lyase
ASRGL1 asparaginase like 1
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CAMP cathelicidin antimicrobial peptide
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CHGB chromogranin B
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCTPP1 dCTP pyrophosphatase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
ECI1 enoyl-CoA delta isomerase 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FERMT1 fermitin family member 1
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FLNA filamin A, alpha
FXYD6 FXYD domain containing ion transport regulator 6
GALE UDP-galactose-4-epimerase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAS1 growth arrest-specific 1
GMDS GDP-mannose 4,6-dehydratase
GMFB glia maturation factor, beta
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HK2 hexokinase 2
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
INHBB inhibin, beta B
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
LAPTM5 lysosomal protein transmembrane 5
LGALS4 lectin, galactoside-binding, soluble, 4
LIG1 ligase I, DNA, ATP-dependent
LOC100505650 uncharacterized LOC100505650
LSR lipolysis stimulated lipoprotein receptor
LTF lactotransferrin
LY96 lymphocyte antigen 96
MARCKSL1 MARCKS-like 1
MCF2L MCF.2 cell line derived transforming sequence-like
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NASP nuclear autoantigenic sperm protein (histone-binding)
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLN phospholamban
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPA1 pyrophosphatase (inorganic) 1
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM223 transmembrane protein 223
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TSPO translocator protein (18kDa)
TSTA3 tissue specific transplantation antigen P35B
TWF2 twinfilin actin binding protein 2
TXNL4A thioredoxin-like 4A
VCAN versican