BRD-A19500257_geldanamycin_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACSM3 acyl-CoA synthetase medium-chain family member 3
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ANKMY2 ankyrin repeat and MYND domain containing 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1QB complement component 1, q subcomponent, B chain
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNG1 cyclin G1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPD carboxypeptidase D
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNASE1L3 deoxyribonuclease I-like 3
DSP desmoplakin
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP1 fatty acid binding protein 1, liver
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FAM8A1 family with sequence similarity 8, member A1
FNBP1 formin binding protein 1
FOXJ3 forkhead box J3
FXR1 fragile X mental retardation, autosomal homolog 1
GAGE3 G antigen 3
GOLGB1 golgin B1
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GUSBP11 glucuronidase, beta pseudogene 11
HAL histidine ammonia-lyase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLHDC10 kelch domain containing 10
KNG1 kininogen 1
KRT13 keratin 13, type I
LAMB1 laminin, beta 1
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LUM lumican
MAN2B1 mannosidase, alpha, class 2B, member 1
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MUT methylmalonyl CoA mutase
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NUCB2 nucleobindin 2
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
OSBPL9 oxysterol binding protein-like 9
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PLA1A phospholipase A1 member A
PRAME preferentially expressed antigen in melanoma
PRCP prolylcarboxypeptidase (angiotensinase C)
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PVALB parvalbumin
QPRT quinolinate phosphoribosyltransferase
RELN reelin
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPS26 ribosomal protein S26
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPRR3 small proline-rich protein 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSFA2 sperm specific antigen 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176A transmembrane protein 176A
TOB1 transducer of ERBB2, 1
TOMM34 translocase of outer mitochondrial membrane 34
TTN titin
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
USP9X ubiquitin specific peptidase 9, X-linked
XBP1 X-box binding protein 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD3 abhydrolase domain containing 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATF3 activating transcription factor 3
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CORO1A coronin, actin binding protein, 1A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTPP1 dCTP pyrophosphatase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EVI2A ecotropic viral integration site 2A
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD5 FXYD domain containing ion transport regulator 5
FXYD6 FXYD domain containing ion transport regulator 6
GCHFR GTP cyclohydrolase I feedback regulator
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBA inhibin, beta A
INHBB inhibin, beta B
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LMCD1 LIM and cysteine-rich domains 1
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL10 oxysterol binding protein-like 10
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLAU plasminogen activator, urokinase
PLN phospholamban
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SET SET nuclear proto-oncogene
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SORBS3 sorbin and SH3 domain containing 3
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
VIM vimentin
WTAP Wilms tumor 1 associated protein
WWTR1 WW domain containing transcription regulator 1
YBX3 Y box binding protein 3