BRD-A19500257_geldanamycin_SKBR3_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

311 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACE2 angiotensin I converting enzyme 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADGRL2 adhesion G protein-coupled receptor L2
AGR2 anterior gradient 2
APOD apolipoprotein D
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCHE butyrylcholinesterase
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BRD8 bromodomain containing 8
C1ORF54 chromosome 1 open reading frame 54
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLGN calmegin
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRTAP cartilage associated protein
CRYZ crystallin, zeta (quinone reductase)
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLRB1 dynein, light chain, roadblock-type 1
EFHC1 EF-hand domain (C-terminal) containing 1
EGF epidermal growth factor
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP1 fatty acid binding protein 1, liver
FAM134B family with sequence similarity 134, member B
FAM134C family with sequence similarity 134, member C
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GRAMD3 GRAM domain containing 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLHDC10 kelch domain containing 10
KNG1 kininogen 1
KRT18 keratin 18, type I
LAMA4 laminin, alpha 4
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LETMD1 LETM1 domain containing 1
LRRC16A leucine rich repeat containing 16A
LUM lumican
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MID1 midline 1
MUT methylmalonyl CoA mutase
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NRIP3 nuclear receptor interacting protein 3
NUCB2 nucleobindin 2
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
ORC4 origin recognition complex, subunit 4
OSBPL9 oxysterol binding protein-like 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PHACTR2 phosphatase and actin regulator 2
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PPID peptidylprolyl isomerase D
PRAME preferentially expressed antigen in melanoma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PVALB parvalbumin
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF11 SR-related CTD-associated factor 11
SCARB2 scavenger receptor class B, member 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SSFA2 sperm specific antigen 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TOMM34 translocase of outer mitochondrial membrane 34
TRAF5 TNF receptor-associated factor 5
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TUG1 taurine up-regulated 1 (non-protein coding)
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPK1B uroplakin 1B
UPK3B uroplakin 3B
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZC3H15 zinc finger CCCH-type containing 15
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAT2 acetyl-CoA acetyltransferase 2
AEBP1 AE binding protein 1
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
AREG amphiregulin
ASPN asporin
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BOP1 block of proliferation 1
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIRBP cold inducible RNA binding protein
CLTB clathrin, light chain B
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRLF1 cytokine receptor-like factor 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FILIP1L filamin A interacting protein 1-like
FKBP11 FK506 binding protein 11, 19 kDa
FOXG1 forkhead box G1
FRZB frizzled-related protein
GAP43 growth associated protein 43
GPRC5A G protein-coupled receptor, class C, group 5, member A
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAUS7 HAUS augmin-like complex, subunit 7
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAG1 jagged 1
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LSR lipolysis stimulated lipoprotein receptor
MACF1 microtubule-actin crosslinking factor 1
MARCKSL1 MARCKS-like 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NCAM1 neural cell adhesion molecule 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PDE8B phosphodiesterase 8B
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PLN phospholamban
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRM spermidine synthase
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
TAGLN transgelin
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
YBX3 Y box binding protein 3
ZFP36L2 ZFP36 ring finger protein-like 2