BRD-A19500257_geldanamycin_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADCY9 adenylate cyclase 9
AKAP9 A kinase (PRKA) anchor protein 9
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANO1 anoctamin 1, calcium activated chloride channel
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP29 Rho GTPase activating protein 29
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPN6 calpain 6
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CRYZ crystallin, zeta (quinone reductase)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EGF epidermal growth factor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM13A family with sequence similarity 13, member A
FGFR2 fibroblast growth factor receptor 2
FNBP1 formin binding protein 1
FOXD1 forkhead box D1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD2 frizzled class receptor 2
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
GRAMD3 GRAM domain containing 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL6ST interleukin 6 signal transducer
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MATN2 matrilin 2
MB myoglobin
MFAP5 microfibrillar associated protein 5
MPPED2 metallophosphoesterase domain containing 2
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NARFL nuclear prelamin A recognition factor-like
NEB nebulin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OGDHL oxoglutarate dehydrogenase-like
OLFML3 olfactomedin-like 3
OSBPL9 oxysterol binding protein-like 9
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PVALB parvalbumin
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RELN reelin
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TOMM34 translocase of outer mitochondrial membrane 34
TPBG trophoblast glycoprotein
TTN titin
TWF1 twinfilin actin binding protein 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIPOQ adiponectin, C1Q and collagen domain containing
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMDHD2 amidohydrolase domain containing 2
ANXA5 annexin A5
ATF3 activating transcription factor 3
C1ORF116 chromosome 1 open reading frame 116
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
DAD1 defender against cell death 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EGR2 early growth response 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXG1 forkhead box G1
FPR1 formyl peptide receptor 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBA inhibin, beta A
INHBB inhibin, beta B
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LMCD1 LIM and cysteine-rich domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP10 low density lipoprotein receptor-related protein 10
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
MMD monocyte to macrophage differentiation-associated
MRPS16 mitochondrial ribosomal protein S16
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PEA15 phosphoprotein enriched in astrocytes 15
PGAM1 phosphoglycerate mutase 1 (brain)
PI3 peptidase inhibitor 3, skin-derived
PMEPA1 prostate transmembrane protein, androgen induced 1
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS13 regulator of G-protein signaling 13
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TCF4 transcription factor 4
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZFP36L2 ZFP36 ring finger protein-like 2
ZWINT ZW10 interacting kinetochore protein