BRD-A19500257_geldanamycin_PHH_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A19500257_geldanamycin_PHH_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADCK3 aarF domain containing kinase 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ATP11B ATPase, class VI, type 11B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
BAG3 BCL2-associated athanogene 3
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EZR ezrin
GPC3 glypican 3
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGHMBP2 immunoglobulin mu binding protein 2
IGLV2-23 immunoglobulin lambda variable 2-23
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITM2A integral membrane protein 2A
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LDLR low density lipoprotein receptor
MAP7 microtubule-associated protein 7
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MYO10 myosin X
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNT nicotinamide nucleotide transhydrogenase
PCDH17 protocadherin 17
PFKM phosphofructokinase, muscle
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
PTCH1 patched 1
PVALB parvalbumin
RAD23B RAD23 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
SON SON DNA binding protein
SORBS2 sorbin and SH3 domain containing 2
SPP1 secreted phosphoprotein 1
SYBU syntabulin (syntaxin-interacting)
TMEM97 transmembrane protein 97
TRAC T cell receptor alpha constant
TSPAN13 tetraspanin 13
WFDC2 WAP four-disulfide core domain 2
WIPF2 WAS/WASL interacting protein family, member 2
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CDC20 cell division cycle 20
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
CRABP2 cellular retinoic acid binding protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMXL2 Dmx-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
GSE1 Gse1 coiled-coil protein
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMB1 laminin, beta 1
LEFTY1 left-right determination factor 1
LRRC17 leucine rich repeat containing 17
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MBD4 methyl-CpG binding domain protein 4
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
PARP2 poly (ADP-ribose) polymerase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PROSC proline synthetase co-transcribed homolog (bacterial)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRO protein tyrosine phosphatase, receptor type, O
RAB31 RAB31, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
VAMP8 vesicle-associated membrane protein 8
VGLL4 vestigial-like family member 4
WASF3 WAS protein family, member 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZFP36L2 ZFP36 ring finger protein-like 2