BRD-A19500257_geldanamycin_OV7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A19500257_geldanamycin_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
DDIT3 DNA-damage-inducible transcript 3
DEFB1 defensin, beta 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGFL6 EGF-like-domain, multiple 6
FAM129A family with sequence similarity 129, member A
FGB fibrinogen beta chain
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GAL galanin/GMAP prepropeptide
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HYOU1 hypoxia up-regulated 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INHBE inhibin, beta E
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LBP lipopolysaccharide binding protein
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1M metallothionein 1M
NKX2-2 NK2 homeobox 2
OLFML3 olfactomedin-like 3
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PHGDH phosphoglycerate dehydrogenase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAT1 phosphoserine aminotransferase 1
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RGCC regulator of cell cycle
RPL10 ribosomal protein L10
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC35B1 solute carrier family 35, member B1
SSR4 signal sequence receptor, delta
TDO2 tryptophan 2,3-dioxygenase
TSKU tsukushi, small leucine rich proteoglycan
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOLD1 apolipoprotein L domain containing 1
ARL4C ADP-ribosylation factor-like 4C
ARMT1 acidic residue methyltransferase 1
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EMP3 epithelial membrane protein 3
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPNMB glycoprotein (transmembrane) nmb
HLF hepatic leukemia factor
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IRS1 insulin receptor substrate 1
KLF2 Kruppel-like factor 2
KRT15 keratin 15, type I
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHFP lipoma HMGIC fusion partner
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MET MET proto-oncogene, receptor tyrosine kinase
MID1 midline 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
PALLD palladin, cytoskeletal associated protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLS1 plastin 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB38 RAB38, member RAS oncogene family
SDC2 syndecan 2
SDPR serum deprivation response
SH3BP4 SH3-domain binding protein 4
SMAD3 SMAD family member 3
SMS spermine synthase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
STOM stomatin
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM123 transmembrane protein 123
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TSPAN4 tetraspanin 4
VSNL1 visinin-like 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF586 zinc finger protein 586