BRD-A19500257_geldanamycin_NEU_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-A19500257_geldanamycin_NEU_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
CAPG capping protein (actin filament), gelsolin-like
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHIT1 chitinase 1 (chitotriosidase)
COL15A1 collagen, type XV, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL4A5 collagen, type IV, alpha 5
CREG1 cellular repressor of E1A-stimulated genes 1
CTSS cathepsin S
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EXPH5 exophilin 5
EZR ezrin
FDX1 ferredoxin 1
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
HSPA8 heat shock 70kDa protein 8
IL17RB interleukin 17 receptor B
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MYOF myoferlin
NLRP2 NLR family, pyrin domain containing 2
OSR2 odd-skipped related transciption factor 2
PCBP2 poly(rC) binding protein 2
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
RPL38 ribosomal protein L38
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
THBS2 thrombospondin 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM176B transmembrane protein 176B
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT5A wingless-type MMTV integration site family, member 5A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARMCX6 armadillo repeat containing, X-linked 6
AUTS2 autism susceptibility candidate 2
CD200 CD200 molecule
CD24 CD24 molecule
CD320 CD320 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK4 cyclin-dependent kinase 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CELF2 CUGBP, Elav-like family member 2
CEP170 centrosomal protein 170kDa
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COCH cochlin
CSNK1E casein kinase 1, epsilon
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCLK1 doublecortin-like kinase 1
DCX doublecortin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
EFS embryonal Fyn-associated substrate
EIF5 eukaryotic translation initiation factor 5
FGF13 fibroblast growth factor 13
FKBP3 FK506 binding protein 3, 25kDa
FLOT2 flotillin 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAP43 growth associated protein 43
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GSPT2 G1 to S phase transition 2
H1FX H1 histone family, member X
HN1L hematological and neurological expressed 1-like
HNRNPM heterogeneous nuclear ribonucleoprotein M
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JADE1 jade family PHD finger 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD5 potassium channel tetramerization domain containing 5
KPNB1 karyopherin (importin) beta 1
LRRC41 leucine rich repeat containing 41
LUC7L3 LUC7-like 3 (S. cerevisiae)
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL12 mitochondrial ribosomal protein L12
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB4 phospholipase C, beta 4
PLP1 proteolipid protein 1
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PSENEN presenilin enhancer gamma secretase subunit
PSIP1 PC4 and SFRS1 interacting protein 1
PTMA prothymosin, alpha
PXMP2 peroxisomal membrane protein 2, 22kDa
RBBP4 retinoblastoma binding protein 4
REEP1 receptor accessory protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SELE selectin E
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIRP SRA stem-loop interacting RNA binding protein
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX11 SRY (sex determining region Y)-box 11
SRSF7 serine/arginine-rich splicing factor 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCEAL2 transcription elongation factor A (SII)-like 2
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLE4 transducin-like enhancer of split 4
TLK2 tousled-like kinase 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMX4 thioredoxin-related transmembrane protein 4
TOP1 topoisomerase (DNA) I
TOP2B topoisomerase (DNA) II beta 180kDa
TOX3 TOX high mobility group box family member 3
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZMYND8 zinc finger, MYND-type containing 8