BRD-A19500257_geldanamycin_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A19500257_geldanamycin_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CAST calpastatin
CBS cystathionine-beta-synthase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
COL5A1 collagen, type V, alpha 1
CORO1A coronin, actin binding protein, 1A
CTSZ cathepsin Z
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EVI2A ecotropic viral integration site 2A
FAM117A family with sequence similarity 117, member A
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
GPR88 G protein-coupled receptor 88
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
KIF1B kinesin family member 1B
KLHL21 kelch-like family member 21
OLFML3 olfactomedin-like 3
PDE8B phosphodiesterase 8B
PITX1 paired-like homeodomain 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPRR3 small proline-rich protein 3
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TUSC3 tumor suppressor candidate 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP3 aquaporin 3 (Gill blood group)
ARHGAP6 Rho GTPase activating protein 6
BEX1 brain expressed, X-linked 1
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHRDL1 chordin-like 1
CLIC5 chloride intracellular channel 5
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DST dystonin
EDNRB endothelin receptor type B
EGR3 early growth response 3
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FGF13 fibroblast growth factor 13
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HOXC6 homeobox C6
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LDB2 LIM domain binding 2
LIMCH1 LIM and calponin homology domains 1
LRRN3 leucine rich repeat neuronal 3
MAMLD1 mastermind-like domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MEG3 maternally expressed 3 (non-protein coding)
MYLK myosin light chain kinase
NCALD neurocalcin delta
NEBL nebulette
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PEG10 paternally expressed 10
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PSIP1 PC4 and SFRS1 interacting protein 1
RNF167 ring finger protein 167
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM255A transmembrane protein 255A
TSPAN8 tetraspanin 8