BRD-A19500257_geldanamycin_NCIH1694_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A19500257_geldanamycin_NCIH1694_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALR calreticulin
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN10 claudin 10
CLDN3 claudin 3
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP14 dual specificity phosphatase 14
EIF1 eukaryotic translation initiation factor 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LARP6 La ribonucleoprotein domain family, member 6
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MEST mesoderm specific transcript
MFAP5 microfibrillar associated protein 5
MMP13 matrix metallopeptidase 13
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
SARS seryl-tRNA synthetase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SST somatostatin
TARS threonyl-tRNA synthetase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TWF2 twinfilin actin binding protein 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
CCNF cyclin F
CLTC clathrin, heavy chain (Hc)
CRH corticotropin releasing hormone
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT2 fibronectin leucine rich transmembrane protein 2
GPX3 glutathione peroxidase 3
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IGF1 insulin-like growth factor 1 (somatomedin C)
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0485 uncharacterized LOC57235
MARCKSL1 MARCKS-like 1
MFSD10 major facilitator superfamily domain containing 10
MTERF3 mitochondrial transcription termination factor 3
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM1 PDZ and LIM domain 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SLC35E3 solute carrier family 35, member E3
SMS spermine synthase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)