BRD-A19500257_geldanamycin_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY7 adenylate cyclase 7
APOE apolipoprotein E
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF4 activating transcription factor 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CACYBP calcyclin binding protein
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP57 centrosomal protein 57kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRELD2 cysteine-rich with EGF-like domains 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EAF2 ELL associated factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
LONP2 lon peptidase 2, peroxisomal
LPL lipoprotein lipase
MANF mesencephalic astrocyte-derived neurotrophic factor
MARCKS myristoylated alanine-rich protein kinase C substrate
MX1 MX dynamin-like GTPase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PLEK pleckstrin
POU2AF1 POU class 2 associating factor 1
RAD9A RAD9 homolog A (S. pombe)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPW1 selenoprotein W, 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
UGDH UDP-glucose 6-dehydrogenase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCND1 cyclin D1
CDC25B cell division cycle 25B
COL4A5 collagen, type IV, alpha 5
CRIP2 cysteine-rich protein 2
CYBRD1 cytochrome b reductase 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EPCAM epithelial cell adhesion molecule
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IL13RA2 interleukin 13 receptor, alpha 2
JUN jun proto-oncogene
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LMO2 LIM domain only 2 (rhombotin-like 1)
NEFL neurofilament, light polypeptide
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDAP1 PDGFA associated protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PFN2 profilin 2
PNMA2 paraneoplastic Ma antigen 2
PRSS2 protease, serine, 2 (trypsin 2)
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX11 SRY (sex determining region Y)-box 11
STC1 stanniocalcin 1
TF transferrin
THAP11 THAP domain containing 11
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
WLS wntless Wnt ligand secretion mediator