BRD-A19500257_geldanamycin_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CACYBP calcyclin binding protein
CAPN6 calpain 6
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEP57 centrosomal protein 57kDa
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPM carboxypeptidase M
CRELD2 cysteine-rich with EGF-like domains 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
FOSL2 FOS-like antigen 2
GNLY granulysin
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
LYZ lysozyme
MANF mesencephalic astrocyte-derived neurotrophic factor
MZB1 marginal zone B and B1 cell-specific protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PGC progastricsin (pepsinogen C)
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
POU2AF1 POU class 2 associating factor 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SERP1 stress-associated endoplasmic reticulum protein 1
THAP11 THAP domain containing 11
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
UGDH UDP-glucose 6-dehydrogenase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
ANXA2 annexin A2
CAST calpastatin
CAV2 caveolin 2
CFD complement factor D (adipsin)
CHGB chromogranin B
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST1 cystatin SN
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DPYSL3 dihydropyrimidinase-like 3
E2F2 E2F transcription factor 2
EGR3 early growth response 3
ETV1 ets variant 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIAA1033 KIAA1033
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
MMP1 matrix metallopeptidase 1
MSRB2 methionine sulfoxide reductase B2
NAV3 neuron navigator 3
NEBL nebulette
NEFL neurofilament, light polypeptide
NID2 nidogen 2 (osteonidogen)
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
OLFM4 olfactomedin 4
PDE9A phosphodiesterase 9A
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLAT plasminogen activator, tissue
PROM1 prominin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCT glutaminyl-peptide cyclotransferase
RFTN1 raftlin, lipid raft linker 1
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican