BRD-A19500257_geldanamycin_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
AFF1 AF4/FMR2 family, member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15B arachidonate 15-lipoxygenase, type B
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AURKA aurora kinase A
BEX4 brain expressed, X-linked 4
C14ORF1 chromosome 14 open reading frame 1
C14ORF132 chromosome 14 open reading frame 132
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD34 CD34 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A2 collagen, type V, alpha 2
COPG1 coatomer protein complex, subunit gamma 1
CPE carboxypeptidase E
CRYZ crystallin, zeta (quinone reductase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GOLGB1 golgin B1
GPC3 glypican 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1RN interleukin 1 receptor antagonist
INTS3 integrator complex subunit 3
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
JUP junction plakoglobin
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLK3 kallikrein-related peptidase 3
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LYPD1 LY6/PLAUR domain containing 1
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAGEH1 melanoma antigen family H1
MEIS2 Meis homeobox 2
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
MYH10 myosin, heavy chain 10, non-muscle
MYO5C myosin VC
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NID2 nidogen 2 (osteonidogen)
NISCH nischarin
NPY neuropeptide Y
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
NXN nucleoredoxin
OLFM1 olfactomedin 1
OLFML3 olfactomedin-like 3
OSBPL9 oxysterol binding protein-like 9
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SARAF store-operated calcium entry-associated regulatory factor
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERP1 stress-associated endoplasmic reticulum protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIK1 salt-inducible kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK26 serine/threonine protein kinase 26
TARP TCR gamma alternate reading frame protein
TMEM45A transmembrane protein 45A
TSPAN13 tetraspanin 13
UFM1 ubiquitin-fold modifier 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VWF von Willebrand factor
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDCP1 CUB domain containing protein 1
CDKN2A cyclin-dependent kinase inhibitor 2A
COTL1 coactosin-like F-actin binding protein 1
CPA3 carboxypeptidase A3 (mast cell)
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD5 FXYD domain containing ion transport regulator 5
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGA1 high mobility group AT-hook 1
HOXB7 homeobox B7
IER3 immediate early response 3
IL17RB interleukin 17 receptor B
ITGA6 integrin, alpha 6
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF6 Kruppel-like factor 6
KRT81 keratin 81, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NELL2 NEL-like 2 (chicken)
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS2 protease, serine, 2 (trypsin 2)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP8 retinoblastoma binding protein 8
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SATB2 SATB homeobox 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
UNG uracil-DNA glycosylase
VCAN versican
WWTR1 WW domain containing transcription regulator 1