BRD-A19500257_geldanamycin_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AQP3 aquaporin 3 (Gill blood group)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
C1S complement component 1, s subcomponent
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSH cathepsin H
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSTN destrin (actin depolymerizing factor)
EFHD1 EF-hand domain family, member D1
EGF epidermal growth factor
EGFL6 EGF-like-domain, multiple 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
JAM3 junctional adhesion molecule 3
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OBSL1 obscurin-like 1
OLFML3 olfactomedin-like 3
OSR2 odd-skipped related transciption factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLLP plasmolipin
PPIB peptidylprolyl isomerase B (cyclophilin B)
QPRT quinolinate phosphoribosyltransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS2 regulator of G-protein signaling 2
RYBP RING1 and YY1 binding protein
SAR1A secretion associated, Ras related GTPase 1A
SC5D sterol-C5-desaturase
SEC61G Sec61 gamma subunit
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SST somatostatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX3 T-box 3
TNNC1 troponin C type 1 (slow)
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C16ORF45 chromosome 16 open reading frame 45
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML5 calmodulin-like 5
CAST calpastatin
CCND1 cyclin D1
CCND2 cyclin D2
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
CEP170 centrosomal protein 170kDa
CST1 cystatin SN
CYBA cytochrome b-245, alpha polypeptide
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM57A family with sequence similarity 57, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6A glycoprotein M6A
HHEX hematopoietically expressed homeobox
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
PDE4B phosphodiesterase 4B, cAMP-specific
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNMA2 paraneoplastic Ma antigen 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTHLH parathyroid hormone-like hormone
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNX10 sorting nexin 10
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WWTR1 WW domain containing transcription regulator 1