BRD-A19500257_geldanamycin_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
AFF1 AF4/FMR2 family, member 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
B3GNT1
BEX1 brain expressed, X-linked 1
BRD8 bromodomain containing 8
C14ORF1 chromosome 14 open reading frame 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
INSR insulin receptor
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT4 keratin 4, type II
LAMP3 lysosomal-associated membrane protein 3
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
MYRF myelin regulatory factor
NEBL nebulette
NISCH nischarin
NOTCH3 notch 3
NUCB2 nucleobindin 2
NXN nucleoredoxin
OBSL1 obscurin-like 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS5 regulator of G-protein signaling 5
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TCF4 transcription factor 4
TMEM97 transmembrane protein 97
TNS1 tensin 1
TSPAN13 tetraspanin 13
UGCG UDP-glucose ceramide glucosyltransferase
YIPF5 Yip1 domain family, member 5
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BIRC2 baculoviral IAP repeat containing 2
BRCA1 breast cancer 1, early onset
CAPN2 calpain 2, (m/II) large subunit
CCND1 cyclin D1
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDCP1 CUB domain containing protein 1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CENPU centromere protein U
COTL1 coactosin-like F-actin binding protein 1
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DOCK4 dedicator of cytokinesis 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FERMT1 fermitin family member 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6A glycoprotein M6A
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IL17RB interleukin 17 receptor B
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
LAMB3 laminin, beta 3
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LRP4 low density lipoprotein receptor-related protein 4
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS3 protease, serine, 3
PTHLH parathyroid hormone-like hormone
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS20 regulator of G-protein signaling 20
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
S100B S100 calcium binding protein B
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMYD2 SET and MYND domain containing 2
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
SYBU syntabulin (syntaxin-interacting)
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TRIB2 tribbles pseudokinase 2
TSPAN5 tetraspanin 5
TYMS thymidylate synthetase
VCAN versican
VEGFC vascular endothelial growth factor C
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
ZFP36L1 ZFP36 ring finger protein-like 1