BRD-A19500257_geldanamycin_MDAMB231_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
AFF1 AF4/FMR2 family, member 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BRD8 bromodomain containing 8
C1ORF115 chromosome 1 open reading frame 115
C1QB complement component 1, q subcomponent, B chain
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1 cyclin B1
CCNG2 cyclin G2
CFB complement factor B
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
DAPK1 death-associated protein kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHDDS dehydrodolichyl diphosphate synthase
DLG5 discs, large homolog 5 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DVL3 dishevelled segment polarity protein 3
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FXR1 fragile X mental retardation, autosomal homolog 1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPC1 glypican 1
GPM6B glycoprotein M6B
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
INSR insulin receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MPPED2 metallophosphoesterase domain containing 2
MSMO1 methylsterol monooxygenase 1
MXD4 MAX dimerization protein 4
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NMU neuromedin U
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
NXN nucleoredoxin
OBSL1 obscurin-like 1
OLFML3 olfactomedin-like 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SIK1 salt-inducible kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TARP TCR gamma alternate reading frame protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TWIST1 twist family bHLH transcription factor 1
WFS1 Wolfram syndrome 1 (wolframin)
YIPF5 Yip1 domain family, member 5
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BRCA1 breast cancer 1, early onset
CCND1 cyclin D1
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC45 cell division cycle 45
CDCP1 CUB domain containing protein 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP170 centrosomal protein 170kDa
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
DDB2 damage-specific DNA binding protein 2, 48kDa
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNMBP dynamin binding protein
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSAP gamma-secretase activating protein
HAT1 histone acetyltransferase 1
HMGA1 high mobility group AT-hook 1
HPCAL1 hippocalcin-like 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JAG1 jagged 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LOXL1 lysyl oxidase-like 1
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MET MET proto-oncogene, receptor tyrosine kinase
MMP1 matrix metallopeptidase 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PTHLH parathyroid hormone-like hormone
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SH2B3 SH2B adaptor protein 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
STX3 syntaxin 3
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TYMS thymidylate synthetase
WWTR1 WW domain containing transcription regulator 1