BRD-A19500257_geldanamycin_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
CADM1 cell adhesion molecule 1
COL9A2 collagen, type IX, alpha 2
DLC1 DLC1 Rho GTPase activating protein
EPHA3 EPH receptor A3
FILIP1L filamin A interacting protein 1-like
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
MYH10 myosin, heavy chain 10, non-muscle
MYL9 myosin, light chain 9, regulatory
NPEPL1 aminopeptidase-like 1
OBSL1 obscurin-like 1
TAGLN transgelin
TBX2 T-box 2
TBX3 T-box 3
TFRC transferrin receptor
THAP11 THAP domain containing 11
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
CBR3 carbonyl reductase 3
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
ETV1 ets variant 1
FAM3C family with sequence similarity 3, member C
FOXG1 forkhead box G1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HMGN5 high mobility group nucleosome binding domain 5
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MMP1 matrix metallopeptidase 1
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
TKTL1 transketolase-like 1
ZBTB18 zinc finger and BTB domain containing 18