BRD-A19500257_geldanamycin_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADGRL4 adhesion G protein-coupled receptor L4
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCP110 centriolar coiled coil protein 110kDa
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLDN4 claudin 4
CLIC5 chloride intracellular channel 5
CRISP3 cysteine-rich secretory protein 3
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFNB2 ephrin-B2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOXJ3 forkhead box J3
G0S2 G0/G1 switch 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
JMJD6 jumonji domain containing 6
KIAA0355 KIAA0355
LCN2 lipocalin 2
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MEF2C myocyte enhancer factor 2C
MOK MOK protein kinase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NEB nebulin
NGRN neugrin, neurite outgrowth associated
PAN2 PAN2 poly(A) specific ribonuclease subunit
PFKM phosphofructokinase, muscle
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
TCF4 transcription factor 4
TMOD1 tropomodulin 1
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSPAN12 tetraspanin 12
TSPYL5 TSPY-like 5
TTN titin
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
BAG1 BCL2-associated athanogene
CD9 CD9 molecule
CD96 CD96 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKB creatine kinase, brain
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXADR coxsackie virus and adenovirus receptor
CYTL1 cytokine-like 1
DENND1B DENN/MADD domain containing 1B
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FKBP5 FK506 binding protein 5
GAGE3 G antigen 3
GCH1 GTP cyclohydrolase 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INA internexin neuronal intermediate filament protein, alpha
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
LAMP1 lysosomal-associated membrane protein 1
LPIN2 lipin 2
MAGEA3 melanoma antigen family A3
MAOB monoamine oxidase B
MMP9 matrix metallopeptidase 9
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NVL nuclear VCP-like
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SATB1 SATB homeobox 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STOM stomatin
TLR4 toll-like receptor 4