BRD-A19500257_geldanamycin_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA6 annexin A6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BPGM 2,3-bisphosphoglycerate mutase
C6ORF62 chromosome 6 open reading frame 62
CALD1 caldesmon 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DST dystonin
DUSP2 dual specificity phosphatase 2
EPAS1 endothelial PAS domain protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHA1 immunoglobulin heavy constant alpha 1
IL2RB interleukin 2 receptor, beta
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KIAA0355 KIAA0355
KRT1 keratin 1, type II
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MSX1 msh homeobox 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAWR PRKC, apoptosis, WT1, regulator
PDGFD platelet derived growth factor D
PDIA5 protein disulfide isomerase family A, member 5
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRK protein tyrosine phosphatase, receptor type, K
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC16A4 solute carrier family 16, member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SYT1 synaptotagmin I
TBL1X transducin (beta)-like 1X-linked
TBX3 T-box 3
TRAC T cell receptor alpha constant
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASCL1 achaete-scute family bHLH transcription factor 1
BEX4 brain expressed, X-linked 4
BGN biglycan
BID BH3 interacting domain death agonist
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CD200 CD200 molecule
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DTX4 deltex 4, E3 ubiquitin ligase
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FHL1 four and a half LIM domains 1
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HEXB hexosaminidase B (beta polypeptide)
HIST1H4C histone cluster 1, H4c
HLA-C major histocompatibility complex, class I, C
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
LCN2 lipocalin 2
LYZ lysozyme
MMP3 matrix metallopeptidase 3
PCP4 Purkinje cell protein 4
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
WTAP Wilms tumor 1 associated protein