BRD-A19500257_geldanamycin_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

365 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADAM10 ADAM metallopeptidase domain 10
ADI1 acireductone dioxygenase 1
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCAM basal cell adhesion molecule (Lutheran blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCL5 chemokine (C-C motif) ligand 5
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CD46 CD46 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CGA glycoprotein hormones, alpha polypeptide
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBL cordon-bleu WH2 repeat protein
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CPD carboxypeptidase D
CRYZ crystallin, zeta (quinone reductase)
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFCAB14 EF-hand calcium binding domain 14
EGFL6 EGF-like-domain, multiple 6
EHF ets homologous factor
EIF4B eukaryotic translation initiation factor 4B
ELF5 E74-like factor 5 (ets domain transcription factor)
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM13A family with sequence similarity 13, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FEM1B fem-1 homolog b (C. elegans)
FN1 fibronectin 1
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
HSBP1 heat shock factor binding protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG2 insulin induced gene 2
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LOC100272216 uncharacterized LOC100272216
LPIN2 lipin 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK2 MAP kinase interacting serine/threonine kinase 2
MKRN1 makorin ring finger protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PFKM phosphofructokinase, muscle
PHF8 PHD finger protein 8
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PNRC1 proline-rich nuclear receptor coactivator 1
PRSS8 protease, serine, 8
PTOV1 prostate tumor overexpressed 1
QPRT quinolinate phosphoribosyltransferase
RAB17 RAB17, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEC11A SEC11 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC1 serine incorporator 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STC1 stanniocalcin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBL1X transducin (beta)-like 1X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THSD7A thrombospondin, type I, domain containing 7A
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM41B transmembrane protein 41B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN1 tetraspanin 1
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AMDHD2 amidohydrolase domain containing 2
ANXA5 annexin A5
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
BHLHE41 basic helix-loop-helix family, member e41
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
C1ORF116 chromosome 1 open reading frame 116
C20ORF27 chromosome 20 open reading frame 27
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNE2 cyclin E2
CD200 CD200 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CKLF chemokine-like factor
CLTB clathrin, light chain B
CXCL14 chemokine (C-X-C motif) ligand 14
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCTPP1 dCTP pyrophosphatase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFS embryonal Fyn-associated substrate
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
EXOSC2 exosome component 2
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FLG filaggrin
GALE UDP-galactose-4-epimerase
GARS glycyl-tRNA synthetase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
JAG1 jagged 1
KANK1 KN motif and ankyrin repeat domains 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
METRN meteorin, glial cell differentiation regulator
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NRIP1 nuclear receptor interacting protein 1
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK1IP1 PAK1 interacting protein 1
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPA1 pyrophosphatase (inorganic) 1
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCRG1 stimulator of chondrogenesis 1
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TAGLN transgelin
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM5 transmembrane protein 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta