BRD-A19500257_geldanamycin_MCF7_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP9A ATPase, class II, type 9A
BID BH3 interacting domain death agonist
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNG2 cyclin G2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CRYZ crystallin, zeta (quinone reductase)
CTGF connective tissue growth factor
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFCAB14 EF-hand calcium binding domain 14
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
FBN2 fibrillin 2
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLPH3L golgi phosphoprotein 3-like
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2AC histone cluster 1, H2ac
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPE1 heat shock 10kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSR insulin receptor
KLHL24 kelch-like family member 24
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
MAP7 microtubule-associated protein 7
MB myoglobin
MKNK2 MAP kinase interacting serine/threonine kinase 2
NBR1 neighbor of BRCA1 gene 1
NFE2L1 nuclear factor, erythroid 2-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PNRC1 proline-rich nuclear receptor coactivator 1
PODXL podocalyxin-like
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRSS8 protease, serine, 8
QPRT quinolinate phosphoribosyltransferase
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
S100P S100 calcium binding protein P
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP1 secretory carrier membrane protein 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
STC1 stanniocalcin 1
STOM stomatin
SYT17 synaptotagmin XVII
TAPBP TAP binding protein (tapasin)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN1 tetraspanin 1
TSPAN6 tetraspanin 6
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
BRCA1 breast cancer 1, early onset
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHN1 chimerin 1
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL2 chemokine (C-X-C motif) ligand 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EREG epiregulin
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGR FGR proto-oncogene, Src family tyrosine kinase
FXYD6 FXYD domain containing ion transport regulator 6
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
IFI44L interferon-induced protein 44-like
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LGALS3 lectin, galactoside-binding, soluble, 3
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUFY3 RUN and FYVE domain containing 3
SFN stratifin
SLBP stem-loop binding protein
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD1 SMAD family member 1
SNAI2 snail family zinc finger 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPIN TIMELESS interacting protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP18 ubiquitin specific peptidase 18