BRD-A19500257_geldanamycin_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
AMOTL2 angiomotin like 2
ARHGAP29 Rho GTPase activating protein 29
BPIFA1 BPI fold containing family A, member 1
CAB39 calcium binding protein 39
CFB complement factor B
CRYZ crystallin, zeta (quinone reductase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GUSBP11 glucuronidase, beta pseudogene 11
H2AFV H2A histone family, member V
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA1A heat shock 70kDa protein 1A
IFITM2 interferon induced transmembrane protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAP2K5 mitogen-activated protein kinase kinase 5
NEBL nebulette
NPTX2 neuronal pentraxin II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PFN2 profilin 2
PGM1 phosphoglucomutase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
REEP1 receptor accessory protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM45A transmembrane protein 45A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ANOS1 anosmin 1
APOD apolipoprotein D
AREG amphiregulin
BHLHE41 basic helix-loop-helix family, member e41
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
CXCL14 chemokine (C-X-C motif) ligand 14
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ENDOD1 endonuclease domain containing 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
INHBA inhibin, beta A
JAG1 jagged 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LOXL1 lysyl oxidase-like 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
NDNF neuron-derived neurotrophic factor
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTX3 pentraxin 3, long
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPP1 secreted phosphoprotein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNGR3 synaptogyrin 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TUBB2A tubulin, beta 2A class IIa
WARS tryptophanyl-tRNA synthetase
WSB2 WD repeat and SOCS box containing 2