BRD-A19500257_geldanamycin_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

276 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
C1S complement component 1, s subcomponent
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CALR calreticulin
CAPN6 calpain 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CDC6 cell division cycle 6
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CETN2 centrin, EF-hand protein, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CST3 cystatin C
CTH cystathionine gamma-lyase
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DERL2 derlin 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EAF2 ELL associated factor 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GOLPH3L golgi phosphoprotein 3-like
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGHA1 immunoglobulin heavy constant alpha 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL6ST interleukin 6 signal transducer
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
LBH limb bud and heart development
LIMCH1 LIM and calponin homology domains 1
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MSMO1 methylsterol monooxygenase 1
MTMR4 myotubularin related protein 4
MZB1 marginal zone B and B1 cell-specific protein
NANS N-acetylneuraminic acid synthase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDZD2 PDZ domain containing 2
PHGDH phosphoglycerate dehydrogenase
POU2AF1 POU class 2 associating factor 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRRC1 proline-rich coiled-coil 1
PSAT1 phosphoserine aminotransferase 1
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SRGN serglycin
SSR4 signal sequence receptor, delta
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUCO SUN domain containing ossification factor
TES testin LIM domain protein
TMEM214 transmembrane protein 214
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CRABP2 cellular retinoic acid binding protein 2
CST1 cystatin SN
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GRB14 growth factor receptor-bound protein 14
HAS2 hyaluronan synthase 2
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KRT15 keratin 15, type I
LAPTM5 lysosomal protein transmembrane 5
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCL1 myeloid cell leukemia 1
MEX3D mex-3 RNA binding family member D
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDN necdin, melanoma antigen (MAGE) family member
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
VCAN versican
VNN1 vanin 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2