BRD-A19500257_geldanamycin_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADCY7 adenylate cyclase 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CAPN6 calpain 6
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CTSE cathepsin E
CXCL2 chemokine (C-X-C motif) ligand 2
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DERL2 derlin 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FAM46C family with sequence similarity 46, member C
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GATA6 GATA binding protein 6
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL6 interleukin 6
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAP prosaposin
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RNASE4 ribonuclease, RNase A family, 4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SQLE squalene epoxidase
STC2 stanniocalcin 2
SUCO SUN domain containing ossification factor
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TTN titin
TUBA1A tubulin, alpha 1a
TYMP thymidine phosphorylase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
AREG amphiregulin
ARHGAP12 Rho GTPase activating protein 12
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1ORF106 chromosome 1 open reading frame 106
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD9 CD9 molecule
CHN1 chimerin 1
CHRDL1 chordin-like 1
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FDX1 ferredoxin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
JADE2 jade family PHD finger 2
KRT17 keratin 17, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MGLL monoglyceride lipase
MRPL15 mitochondrial ribosomal protein L15
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1 PDZ domain containing 1
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRPF4 pre-mRNA processing factor 4
PRR15L proline rich 15-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTMA prothymosin, alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXDN peroxidasin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WEE1 WEE1 G2 checkpoint kinase
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2