BRD-A19500257_geldanamycin_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AGR2 anterior gradient 2
ALOX5 arachidonate 5-lipoxygenase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CACYBP calcyclin binding protein
CALR calreticulin
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLINT1 clathrin interactor 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CST6 cystatin E/M
DDIT3 DNA-damage-inducible transcript 3
DEFB1 defensin, beta 1
DERL2 derlin 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FBXO11 F-box protein 11
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FICD FIC domain containing
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLPH3L golgi phosphoprotein 3-like
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHA1 immunoglobulin heavy constant alpha 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT19 keratin 19, type I
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
LTF lactotransferrin
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEBL nebulette
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODAM odontogenic, ameloblast asssociated
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PIR pirin (iron-binding nuclear protein)
PLD3 phospholipase D family, member 3
PMP22 peripheral myelin protein 22
POU2AF1 POU class 2 associating factor 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRPR signal recognition particle receptor (docking protein)
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TESC tescalcin
TMEM41B transmembrane protein 41B
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFI complement factor I
CHGB chromogranin B
CSTA cystatin A (stefin A)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM60A family with sequence similarity 60, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP5 FK506 binding protein 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GRB14 growth factor receptor-bound protein 14
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IRS1 insulin receptor substrate 1
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
JUNB jun B proto-oncogene
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL2 lysyl oxidase-like 2
MME membrane metallo-endopeptidase
MRPS28 mitochondrial ribosomal protein S28
MT2A metallothionein 2A
MTERF3 mitochondrial transcription termination factor 3
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKG7 natural killer cell granule protein 7
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK1IP1 PAK1 interacting protein 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFA platelet-derived growth factor alpha polypeptide
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRSS3 protease, serine, 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RGS17 regulator of G-protein signaling 17
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SOX11 SRY (sex determining region Y)-box 11
SPAG4 sperm associated antigen 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TBX2 T-box 2
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
VCAN versican
VSNL1 visinin-like 1
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2