BRD-A19500257_geldanamycin_MCF10A_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

280 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF10A_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM12 ADAM metallopeptidase domain 12
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP4 aquaporin 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCL1 achaete-scute family bHLH transcription factor 1
BAG3 BCL2-associated athanogene 3
C1ORF115 chromosome 1 open reading frame 115
C1S complement component 1, s subcomponent
CACYBP calcyclin binding protein
CAPN6 calpain 6
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD99 CD99 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CFB complement factor B
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
COBL cordon-bleu WH2 repeat protein
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRELD2 cysteine-rich with EGF-like domains 2
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDNRB endothelin receptor type B
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IQCG IQ motif containing G
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0226L KIAA0226-like
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
LYZ lysozyme
MALT1 MALT1 paracaspase
MANF mesencephalic astrocyte-derived neurotrophic factor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MREG melanoregulin
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSMO1 methylsterol monooxygenase 1
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPW1 selenoprotein W, 1
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC16A4 solute carrier family 16, member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP10B ATPase, class V, type 10B
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRDL1 chordin-like 1
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CTSC cathepsin C
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD3 EH-domain containing 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP5 FK506 binding protein 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
HAS2 hyaluronan synthase 2
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOXB6 homeobox B6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
LEPR leptin receptor
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NKG7 natural killer cell granule protein 7
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLN phospholamban
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN1 regulator of calcineurin 1
RGS17 regulator of G-protein signaling 17
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WLS wntless Wnt ligand secretion mediator
ZBTB16 zinc finger and BTB domain containing 16
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2